Ayyaz Laboratory - Publications

Publicaions

Selected Articles:

Chua J, Sakthivel P, Kaur A, Allapitan E, Maqsood A, Bathe OF, Minoo P, Ayyaz A.

Aberrant NOTUM+ Program Induced in LGR5+ Crypt Base Columnar Cells Maintains an Immunosuppressive Niche in Colorectal Cancer.

bioRxiv (doi: https://doi.org/10.1101/2025.03.10.642301)

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Ayyaz A, Kumar S, Sangiorgi B, Ghoshal B, Gosio J, Ouladan S, Fink M,BarutcuS, Trcka D, Shen J, Chan K, Wrana JL and Gregorieff A.

Single-Cell Transcriptomes Of The Regenerating Intestine Reveal A Revival Stem Cell.

Nature 569 (7754), 121-125 (2019).

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Baghdadi MB, Houtekamer RM, Perrin L, Rao-Bhatia A, Whelen M, Decker L, Bergert M, Pérez-Gonzàlez C, Bouras R, Gropplero G, Loe AKH, Afkhami-Poostchi A, Chen X, Huang X, Descroix S, Wrana JL, Diz-Muñoz A, Gloerich M, Ayyaz A, Matic Vignjevic D, Kim TH.

PIEZO-dependent mechanosensing is essential for intestinal stem cell fate decision and maintenance.

Science 29;386 (6725), eadj7615 (2024).

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Fink M, Njah K, Patel SJ, Cook DP, Man V, Ruso F, Rajan A, Narimatsu M, Obersterescu A, Pye MJ, Trcka D, Chan K, Ayyaz A, Wrana JL.

Chromatin remodelling in damaged intestinal crypts orchestrates redundant TGFβ and Hippo signalling to drive regeneration

Nature Cell Biology (2024).

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Chua J,Gregorieff A, Ayyaz A.

Bottom-up or Top-down: Inflammation Reprograms Paneth Cells to Develop Bowel Cancers

Cancer Research 84(20):3324-3326 (2024).

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Morral C*, Ayyaz A*, Kuo HC*, Fink M, Verginadis I, Daniel AR, Burner DN, Driver LM, Satow S, Hasapis S, Ghinnagow R, Luo L, Ma Y, Attardi LD, Koumenis C, Minn A, Wrana JL, Lee CL, Kirsch DG (*equal contribution)

p53 Promotes Revival Stem Cells In The Regenerating Intestine After Severe Radiation Injury

Nature Communications 15: 3018 (2024).

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Dervovic D, Chen ELY, Malik A, Afiuni S, Boucher J, Berman JM, Teng K, Ayyaz A, Lu YQ, Narimatsu M, Mbamalu, Loganathan S, Martinez S, Tsai R, Lee JB, Zhang L, Wrana J, Roux PP, Jackson HW, Schramek D.

In Vivo CRISPR Screens Reveal Serpinb9 And Adam2 as Regulators Of Immune Therapy Response In Lung Cancer

Nature Communications 14: 3150 (2023).

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Rahme BS, Lestradet M, Venanzio GD, Ayyaz A, Yamba MW, Lazzaro M, Liegeois S, Vescovi EG, Ferrandon D.

The fliR Gene Contributes To The Virulence Of S. marcescens In A Drosophila Intestinal Infection Model.

Scientific Reports 12, 3068 (2022).

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Baghdadi MB, Ayyaz A, Coquenlorge S, Chu B, Kumar S, Streutker C, Wrana JL, Kim TH.

Enteric Glial Cell Heterogeneity Regulates Intestinal Stem Cell Niches.

Cell Stem Cell 29 (1), 86-100 (2021).

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Goldsmith JR, Spitofsky N, Zamani A, Hood R, Boggs A, Li X, Li M, Reiner E, Ayyaz A, Etwebi Z, Lu L, Rivera Guzman J, Bou-Dargham MJ, Cathoupolis T, Hakonarson H, Sun H, Wrana JL, Gonzalez MV, Chen YH.

TNFAIP8 Controls Murine Intestinal Stem Cell Homeostasis and Regeneration by Regulating Microbiome-Induced Akt Signaling.

Nature Communications 11, Article number: 2591 (2020).

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Ayyaz A, Attisano L and Wrana JL.

Recent Advances in Understanding Contextual TGFβ Signaling.

F1000 Research 6 (F1000 Faculty Rev.): 749 (2017).

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Sousa-Victor P, Ayyaz A, Yayashi R, Qi Y, Madden DT, Lunyak VV, and Jasper H.

Piwi Is Required to Limit Exhaustion Of Aging Somatic Stem Cells.

Cell Reports 20 (11): 2527-2537 (2017).

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Ayyaz A, Hongjie L and Jasper H.